Počet záznamů: 1
Intrinsic nitric oxide-stimulatory activity of lipoteichoic acids from different Gram-positive bacteria
- 1.0348719 - ÚEM 2011 RIV NL eng J - Článek v odborném periodiku
Zídek, Zdeněk - Farghali, H. - Kmoníčková, Eva
Intrinsic nitric oxide-stimulatory activity of lipoteichoic acids from different Gram-positive bacteria.
Nitric Oxide-Biology and Chemistry. Roč. 23, č. 4 (2010), s. 300-310. ISSN 1089-8603. E-ISSN 1089-8611
Grant CEP: GA ČR GA305/08/0535
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: Lipoteichoic acid * Gram-positive bacteria * Nitric oxide
Kód oboru RIV: FR - Farmakologie a lékárnická chemie
Impakt faktor: 3.384, rok: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0348719_01.pdf
The cell wall of Gram-positive bacteria conain large amounts of lipoteichoic acid (LTA). We have found that LTA is endowed with immunostimulatory properties, the expression of which depends on its bacterial source. It has been demonstrated LTA shows positive response in Limulus amoebocyte assay (LAL), mimicking thus lipopolysaccharide (LPS) of Gram-negative bacteria. Similar to LPS, LTA binds to the antibiotics polymyxinB.
Trvalý link: http://hdl.handle.net/11104/0189162
Počet záznamů: 1