Počet záznamů: 1
beta-1,2,3-Triazolyl-Nucleosides as Nicotinamide Riboside Mimics
- 1.0344010 - ÚEB 2011 RIV US eng J - Článek v odborném periodiku
Amigues, E.J. - Armstrong, E. - Dvořáková, Marcela - Migaud, M.E. - Huang, M.
beta-1,2,3-Triazolyl-Nucleosides as Nicotinamide Riboside Mimics.
Nucleosides Nucleotides & Nucleic Acids. Roč. 28, č. 3 (2009), s. 238-259. ISSN 1525-7770. E-ISSN 1532-2335
Výzkumný záměr: CEZ:AV0Z50380511
Klíčová slova: Nucleoside * nucleotide * sirtuin
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 0.768, rok: 2009
The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.
Trvalý link: http://hdl.handle.net/11104/0186347
Počet záznamů: 1