Melatonin interactions with blood pressure and vascular function during l-NAME-induced hypertension

0343240 - FGÚ 2011 RIV DK eng J - Článek v odborném periodiku
Paulis, L. - Pecháňová, Olga - Zicha, Josef - Barta, A. - Gardlik, R. - Celec, P. - Kuneš, Jaroslav - Šimko, F.
Melatonin interactions with blood pressure and vascular function during l-NAME-induced hypertension.
Journal of Pineal Research. Roč. 48, č. 2 (2010), s. 102-108. ISSN 0742-3098. E-ISSN 1600-079X
Grant CEP: GA AV ČR(CZ) IAA500110902
Grant ostatní: VEGA(SK) 1/0187/09; VEGA(SK) 2/0178/09; APVV(SK) 0538-07; EC(XE) 2009-237834
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: endothelium-derived constricting factor * melatonin * nitric oxide
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 5.855, rok: 2010

To elucidate the possible role of the nitric oxide (NO) pathway in the hemodynamic actions of melatonin, the effects of this indolamine on vascular function during hypertension induced by NO-synthase (NOS) inhibition were investigated. It is evident that, in addition to the reduction of the oxidative load, the restoration of the NO pathway seems to play an important role in the antihypertensive effect of melatonin
Trvalý link: http://hdl.handle.net/11104/0185759