Eye-specific expression of an ancestral jellyfish PaxB gene interferes with Pax6 function despite its conserved Pax6/Pax2 characteristics

0333811 - ÚMG 2010 RIV ES eng J - Článek v odborném periodiku
Růžičková, Jana - Piatigorsky, J. - Kozmik, Zbyněk
Eye-specific expression of an ancestral jellyfish PaxB gene interferes with Pax6 function despite its conserved Pax6/Pax2 characteristics.
International Journal of Developmental Biology. Roč. 53, č. 4 (2009), s. 469-482. ISSN 0214-6282. E-ISSN 1696-3547
Grant CEP: GA AV ČR IAA500520908; GA MŠMT(CZ) 1M0520; GA ČR GA204/08/1618
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: Eye * Pax * lens
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.161, rok: 2009

Pax transcription factors are evolutionarily conserved regulators of eye development and can be distinguished on the basis of three functional domains: two DNA-binding domains (the paired domain and the paired-type homeodomain), and the octapeptide motif. PaxB of the eyed cubozoan jellyfish, Tripedalia cystophora, is characterized by a Pax2-like paired domain and octapeptide, and a Pax6-like homeodomain. In mice, functionally distinct Pax6 and Pax2 proteins have unique as well as redundant roles in eye morphogenesis. Here, we show that expression of the jellyfish PaxB gene in mouse embryonic eye tissues impairs normal development of lens and retina.
Trvalý link: http://hdl.handle.net/11104/0178715