Surface plasmon resonance biosensor with anti-crossing modulation readout

0587296 - FZÚ 2025 RIV NL eng J - Článek v odborném periodiku
Hasler, R. - Cattozzo Mor, Dario - Aktug, Gizem - Fossati, Stefan - Vu, V.T. - Tamayo, A. - Giordani, E. - Ricciardi, E. - Giacomini, P. - Perutka, J. - Önder, K. - Kleber, Ch. - Samori, P. - Huang, Ch.-J. - Dostálek, Jakub
Surface plasmon resonance biosensor with anti-crossing modulation readout.
Sensors and Actuators B - Chemical. Roč. 417, Oct (2024), č. článku 136163. E-ISSN 0925-4005
Grant CEP: GA ČR(CZ) GC22-30456J; GA MŠMT(CZ) EH22_008/0004596
GRANT EU: European Commission(XE) 101046217 - VerSiLiB
Institucionální podpora: RVO:68378271
Klíčová slova: grating-coupled surface plasmon resonance * multi-periodic grating * nanoimprint lithography * biosensor * multiplexing * antifouling biointerface
Obor OECD: Optics (including laser optics and quantum optics)
Impakt faktor: 8.4, rok: 2022
Způsob publikování: Open access

A novel approach to surface plasmon resonance (SPR) biosensors providing simplified label-free monitoring of biomolecular affinity binding events is reported. It is based on the interrogation of anti-crossing surface plasmon modes traveling along opposite interfaces of a thin metal film on the top of a tailored multi-periodic grating structure. It allows for diffraction-based backside excitation of surface plasmons without the need of optical matching of the sensor chip to a prism and it allows avoiding of optical probing through the analyzed liquid sample. In conjunction with low angular dispersion of resonantly excited surface plasmon modes, it provides sensitive and versatile optical interrogation of SPR changes associated with biomolecular binding-induced refractive index variations.
Trvalý link: https://hdl.handle.net/11104/0354546


Vědecká data: Zenodo