Počet záznamů: 1
Impaired fin regeneration and angiogenesis in aged zebrafish and turquoise killifish
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SYSNO ASEP 0573121 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Impaired fin regeneration and angiogenesis in aged zebrafish and turquoise killifish Tvůrce(i) Örling, J. (FI)
Kosonen, K. (FI)
Villman, J. (FI)
Reichard, Martin (UBO-W) RID, ORCID, SAI, SAI
Paatero, I. (FI)Celkový počet autorů 5 Číslo článku bio059622 Zdroj.dok. Biology Open. - : Company of Biologists - ISSN 2046-6390
Roč. 12, č. 4 (2023)Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Zebrafish ; Danio rerio ; Turquoise killifish ; Nothobranchius furzeri ; Aging ; Wound healing ; Angiogenesis ; vegf ; Regeneration ; Fin Vědní obor RIV EG - Zoologie Obor OECD Zoology Způsob publikování Open access Institucionální podpora UBO-W - RVO:68081766 UT WOS 000995438100003 EID SCOPUS 85182704988 DOI 10.1242/bio.059622 Anotace Impaired wound healing is associated with aging and has significant effects on human health on an individual level, but also on the whole health-care sector. Deficient angiogenesis appears to be involved in the process, but the underlying biology is still poorly understood. This is at least partially being explained by complexity and costs in using mammalian aging models. To understand aging-related vascular biology of impaired wound healing, we used zebrafish and turquoise killifish fin regeneration models. The regeneration of caudal fin after resection was significantly reduced in old individuals in both species. Age-related changes in angiogenesis, vascular density and expression levels of angiogenesis biomarker VEGF-A were observed. Furthermore, the anti-angiogenic drug vascular endothelial growth factor receptor blocking inhibitor SU5416 reduced regeneration, indicating a key role for angiogenesis in the regeneration of aging caudal fin despite aging-related changes in vasculature. Taken together, our data indicate that these fish fin regeneration models are suitable for studying aging-related decline in wound healing and associated alterations in aging vasculature. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2024 Elektronická adresa https://journals.biologists.com/bio/article/12/4/bio059622/306265/Impaired-fin-regeneration-and-angiogenesis-in-aged
Počet záznamů: 1