The outcome of early life status epilepticus-lessons from laboratory animals

0571990 - FGÚ 2024 RIV US eng J - Článek v odborném periodiku
Kubová, Hana - Mikulecká, Anna - Mareš, Pavel
The outcome of early life status epilepticus-lessons from laboratory animals.
Epilepsia Open. Roč. 8, Suppl.1 (2023), S90-S109. E-ISSN 2470-9239
Grant CEP: GA MŠMT(CZ) LX22NPO5107; GA ČR(CZ) GA19-11931S
Institucionální podpora: RVO:67985823
Klíčová slova: animal models * comorbidites * immature rodent * status epilepticus
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 3, rok: 2022
Způsob publikování: Open access
https://doi.org/10.1002/epi4.12664

Status epilepticus (SE) is the most common neurologic emergency in children. Both clinical and laboratory studies have demonstrated that SE in early life can cause brain damage and permanent behavioral abnormalities, trigger epileptogenesis, and interfere with normal brain development. In experimental rodent models, the consequences of seizures are dependent upon age, the model used, and seizure duration. In studies involving neonatal and infantile animals, the model used, experimental design, conditions during the experiment, and manipulation of animals can significantly affect the course of the experiments as well as the results obtained. Standardization of laboratory approaches, harmonization of scientific methodology, and improvement in data collection can improve the comparability of data among laboratories.
Trvalý link: https://hdl.handle.net/11104/0342835