Počet záznamů: 1
Myocardial development in crocodylians
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SYSNO ASEP 0565665 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Myocardial development in crocodylians Tvůrce(i) Kvasilová, A. (CZ)
Gregorovičová, Martina (FGU-C) RID, ORCID, SAI
Olejníčková, Veronika (FGU-C) RID, ORCID, SAI
Kolesová, Hana (FGU-C) RID, ORCID, SAI
Sedmera, David (FGU-C) RID, ORCID, SAIZdroj.dok. Developmental Dynamics. - : Wiley - ISSN 1058-8388
Roč. 251, č. 12 (2022), s. 2029-2047Poč.str. 19 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova cardiac conduction system ; crocodile embryo ; heart ; optical mapping ; septation ; vasculogenesis Obor OECD Developmental biology CEP GA16-02972S GA ČR - Grantová agentura ČR LTC17023 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LM2015062 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LX22NPO5104 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000853874800001 EID SCOPUS 85138082446 DOI https://doi.org/10.1002/dvdy.527 Anotace Background:Recent reports confirmed the notion that there exists a rudimentary cardiac conduction system (CCS) in the crocodylian heart, and development of its ventricular part is linked to septation. We thus analyzed myocardial development with the emphasis on the CCS components and vascularization in two different crocodylian species.Results:Using optical mapping and HNK-1 immunostaining, pacemaker activity was localized to the right-sided sinus venosus. The atrioventricular conduction was restricted to dorsal part of the atrioventricular canal. Within the ventricle, the impulse was propagated from base-to-apex initially by the trabeculae, later by the ventricular septum, in which strands of HNK-1 positivity were temporarily observed. Completion of ventricular septation correlated with transition of ventricular epicardial activation pattern to mature apex-to-base direction from two periapical foci. Despite a gradual thickening of the ventricular wall, no morphological differentiation of the Purkinje network was observed. Thin-walled coronary vessels with endothelium positive for QH1 obtained a smooth muscle coat after septation. Intramyocardial vessels were abundant especially in the rapidly thickening left ventricular wall.Conclusions:Most of the CCS components present in the homeiotherm hearts can be identified in the developing crocodylian heart, with a notable exception of the Purkinje network distinct from the trabeculae carneae. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1002/dvdy.527
Počet záznamů: 1