Počet záznamů: 1
Engineered Delivery of Dental Stem-Cell-Derived Extracellular Vesicles for Periodontal Tissue Regeneration
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SYSNO ASEP 0558806 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Engineered Delivery of Dental Stem-Cell-Derived Extracellular Vesicles for Periodontal Tissue Regeneration Tvůrce(i) Zárubová, Jana (FGU-C) RID, ORCID
Hasani-Sadrabadi, M. M. (US)
Dashtimoghadam, E. (US)
Zhang, X. (US)
Ansari, S. (US)
Li, S. (US)
Moshaverinia, A. (US)Celkový počet autorů 7 Číslo článku 2102593 Zdroj.dok. Advanced Healthcare Materials. - : Wiley - ISSN 2192-2640
Roč. 11, č. 12 (2022)Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova extracellular vesicles ; immunoengineering ; local drug delivery ; periodontal tissue healing ; periodontitis Obor OECD Dentistry, oral surgery and medicine Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000764955700001 EID SCOPUS 85125564359 DOI 10.1002/adhm.202102593 Anotace Periodontal disease begins as an inflammatory response to a bacterial biofilm deposited around the teeth, which over time leads to the destruction of tooth-supporting structures and consequently tooth loss. Conventional treatment strategies show limited efficacy in promoting regeneration of damaged periodontal tissues. Here, a delivery platform is developed for small extracellular vesicles (sEVs) derived from gingival mesenchymal stem cells (GMSCs) to treat periodontitis. EVs can achieve comparable therapeutic effects to their cells of origin. However, the short half-lives of EVs after their administration along with their rapid diffusion away from the delivery site necessitate frequent administration to achieve therapeutic benefits. To address these issues, “dual delivery” microparticles are engineered enabling microenvironment-sensitive release of EVs by metalloproteinases at the affected site along with antibiotics to suppress bacterial biofilm growth. GMSC sEVs are able to decrease the secretion of pro-inflammatory cytokines by monocytes/macrophages and T cells, suppress T-cell activation, and induce the formation of T regulatory cells (Tregs) in vitro and in a rat model of periodontal disease. One-time administration of immunomodulatory GMSC sEV-decorated microparticles leads to a significant improvement in regeneration of the damaged periodontal tissue. This approach will have potential clinical applications in the regeneration of a variety of tissues. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1002/adhm.202102593
Počet záznamů: 1