Počet záznamů: 1
Effects of Workers Exposure to Nanoparticles Studied by NMR Metabolomics.
- 1.
SYSNO ASEP 0544564 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Effects of Workers Exposure to Nanoparticles Studied by NMR Metabolomics. Tvůrce(i) Horník, Štěpán (UCHP-M) ORCID, RID, SAI
Michálková, Lenka (UCHP-M) RID, ORCID, SAI
Sýkora, Jan (UCHP-M) RID, ORCID, SAI
Ždímal, Vladimír (UCHP-M) RID, ORCID, SAI
Vlčková, Š. (CZ)
Dvořáčková, Š. (CZ)
Pelclová, D. (CZ)Číslo článku 6601 Zdroj.dok. Applied Sciences-Basel. - : MDPI
Roč. 11, č. 4 (2021)Poč.str. 18 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova exhaled breath condensate ; human plasma ; nanoparticles exposure ; NMR metabolomics Vědní obor RIV DN - Vliv životního prostředí na zdraví Obor OECD Environmental sciences (social aspects to be 5.7) CEP LM2018122 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy TK02010035 GA TA ČR - Technologická agentura ČR Způsob publikování Open access Institucionální podpora UCHP-M - RVO:67985858 UT WOS 000675931400001 EID SCOPUS 85111257168 DOI 10.3390/app11146601 Anotace In this study, the effects of occupational exposure to nanoparticles (NPs) were studied by NMR metabolomics. Exhaled breath condensate (EBC) and blood plasma samples were obtained from a research nanoparticles-processing unit at a national research university. The samples were taken from three groups of subjects: samples from workers exposed to nanoparticles collected before and after shift, and from controls not exposed to NPs. Altogether, 601H NMR spectra of exhaled breath condensate (EBC) samples and 601H NMR spectra of blood plasma samples were analysed, 20 in each group. The metabolites identified together with binning data were subjected to multivariate statistical analysis, which provided clear discrimination of the groups studied. Statistically sig-nificant metabolites responsible for group separation served as a foundation for analysis of im-paired metabolic pathways. It was found that the acute effect of NPs exposure is mainly reflected in the pathways related to the production of antioxidants and other protective species, while the chronic effect is manifested mainly in the alteration of glutamine and glutamate metabolism, and the purine metabolism pathway. Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/2076-3417/11/14/6601
Počet záznamů: 1