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Obesity-Induced Changes in Bone Marrow Homeostasis
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SYSNO ASEP 0531064 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Obesity-Induced Changes in Bone Marrow Homeostasis Tvůrce(i) Beňová, Andrea (FGU-C) ORCID
Tencerová, Michaela (FGU-C) RID, ORCIDČíslo článku 294 Zdroj.dok. Frontiers in Endocrinology. - : Frontiers Media - ISSN 1664-2392
Roč. 11, May 12 (2020)Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova bone marrow microenvironment ; bone marrow mesenchymal stem cells ; hematopoietic stem cells ; immune responses ; obesity ; life-style interventions Vědní obor RIV EA - Morfologické obory a cytologie Obor OECD Cell biology CEP GA20-03586S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000537214700001 EID SCOPUS 85086522610 DOI 10.3389/fendo.2020.00294 Anotace Obesity is characterized by low-grade inflammation, which is accompanied by increased accumulation of immune cells in peripheral tissues including adipose tissue (AT), skeletal muscle, liver and pancreas, thereby impairing their primary metabolic functions in the regulation of glucose homeostasis. Obesity has also shown to have a detrimental effect on bone homeostasis by altering bone marrow and hematopoietic stem cell differentiation and thus impairing bone integrity and immune cell properties. The origin of immune cells arises in the bone marrow, which has been shown to be affected with the obesogenic condition via increased cellularity and shifting differentiation and function of hematopoietic and bone marrow mesenchymal stem cells in favor of myeloid progenitors and increased bone marrow adiposity. These obesity-induced changes in the bone marrow microenvironment lead to dramatic bone marrow remodeling and compromising immune cell functions, which in turn affect systemic inflammatory conditions and regulation of whole-body metabolism. However, there is limited information on the inflammatory secretory factors creating the bone marrow microenvironment and how these factors changed during metabolic complications. This review summarizes recent findings on inflammatory and cellular changes in the bone marrow in relation to obesity and further discuss whether dietary intervention or physical activity may have beneficial effects on the bone marrow microenvironment and whole-body metabolism. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2021 Elektronická adresa https://www.frontiersin.org/articles/10.3389/fendo.2020.00294/full
Počet záznamů: 1