Počet záznamů: 1
Electrophoretic Deposition and Characterization of\nFunctional Coatings Based on an Antibacterial\nGallium (III)‐Chitosan Complex
- 1.0524683 - ÚFM 2021 RIV CH eng J - Článek v odborném periodiku
Akhtar, M. A. - Hadzhieva, Z. - Dlouhý, Ivo - Boccaccini, A. R.
Electrophoretic Deposition and Characterization of
Functional Coatings Based on an Antibacterial
Gallium (III)‐Chitosan Complex.
Coatings. Roč. 10, č. 5 (2020), č. článku 483. ISSN 2079-6412. E-ISSN 2079-6412
Institucionální podpora: RVO:68081723
Klíčová slova: gallium * chitosan * electrophoretic deposition * antibacterial coatings * bioactivity
Obor OECD: Coating and films
Impakt faktor: 2.881, rok: 2020
Způsob publikování: Open access
https://www.mdpi.com/2079-6412/10/5/483
Despite their broad biomedical applications in orthopedics and dentistry, metallic
implants are still associated with failures due to their lack of surface biofunctionality, leading to
prosthesis‐related microbial infections. In order to address this issue, the current study focuses on
the fabrication and characterization of a novel type of antibacterial coating based on gallium (III)‐
chitosan (Ga (III)‐CS) complex layers deposited on metallic substrates via electrophoretic deposition
(EPD). Aiming for the production of homogeneous and monophasic coatings, a two step‐procedure
was applied: the first step involved the synthesis of the Ga (III)‐CS complex, followed by EPD from
suitable solutions in an acetic acid–aqueous solvent. The influence of Ga (III) concentration on the
stability of the suspensions was evaluated in terms of zeta potential. Fourier transform infrared
(FTIR) and energy dispersive X‐ray (EDX) spectroscopic analyses indicated the chelation of CS with
Ga (III) within the coatings, while scanning electron microscopy (SEM) confirmed that no additional
metallic gallium deposited during EPD. Furthermore, the results demonstrated that the wettability,
mechanical properties, swelling ability, and enzymatic degradation of the coatings were affected by
the quantity of Ga (III) ions. Colony forming unit (CFU) tests showed a strong synergistic effect
between CS and Ga (III) in inhibiting Escherichia coli strain growth compared to control CS samples.
An in vitro study with MG‐63 cells showed that Ga (III)‐containing coatings were not toxic after 24 h of
incubation.
Trvalý link: http://hdl.handle.net/11104/0309675
Počet záznamů: 1