Počet záznamů: 1
The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy
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SYSNO ASEP 0521636 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy Tvůrce(i) Plzák, J. (CZ)
Bouček, J. (CZ)
Bandurova, V. (CZ)
Kolář, Michal (UMG-J) RID, ORCID
Hradilová, Miluše (UMG-J)
Szabo, P. (CZ)
Lacina, L. (CZ)
Chovanec, M. (CZ)
Smetana, K. (CZ)Celkový počet autorů 9 Číslo článku 440 Zdroj.dok. Cancers (Basel). - : MDPI - ISSN 2072-6694
Roč. 11, č. 4 (2019)Poč.str. 19 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova cancer ; cancer microenvironment ; cancer ecosystem ; cancer-associated fibroblast ; extracellular matrix ; cytokine ; il-6 ; tumour-associated macrophages ; cancer therapy Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology CEP LQ1604 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UMG-J - RVO:68378050 UT WOS 000467773400008 DOI https://doi.org/10.3390/cancers11040440 Anotace Similarly to other types of malignant tumours, the incidence of head and neck cancer is increasing globally. It is frequently associated with smoking and alcohol abuse, and in a broader sense also with prolonged exposure to these factors during ageing. A higher incidence of tumours observed in younger populations without a history of alcohol and tobacco abuse may be due to HPV infection. Malignant tumours form an intricate ecosystem of cancer cells, fibroblasts, blood/lymphatic capillaries and infiltrating immune cells. This dynamic system, the tumour microenvironment, has a significant impact on the biological properties of cancer cells. The microenvironment participates in the control of local aggressiveness of cancer cells, their growth, and their consequent migration to lymph nodes and distant organs during metastatic spread. In cancers originating from squamous epithelium, a similarity was demonstrated between the cancer microenvironment and healing wounds. In this review, we focus on the specificity of the microenvironment of head and neck cancer with emphasis on the mechanism of intercellular crosstalk manipulation for potential therapeutic application. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2020 Elektronická adresa https://www.mdpi.com/2072-6694/11/4/440
Počet záznamů: 1