Počet záznamů: 1
A simple and efficient procedure for capillary blood spiking with basic and acidic drugs for subsequent dried blood spot analysis
- 1.
SYSNO ASEP 0509090 Druh ASEP A - Abstrakt Zařazení RIV Záznam nebyl označen do RIV Zařazení RIV Není vybrán druh dokumentu Název A simple and efficient procedure for capillary blood spiking with basic and acidic drugs for subsequent dried blood spot analysis Tvůrce(i) Dvořák, Miloš (UIACH-O)
Ryšavá, Lenka (UIACH-O) RID, ORCID, SAI
Kubáň, Pavel (UIACH-O) RID, ORCIDCelkový počet autorů 3 Zdroj.dok. CECE 2019. - Gdańsk : University of Gdańsk, 2019
S. 25-25Poč.str. 1 s. Forma vydání Nosič - C Akce CECE 2019. International Interdisciplinary Meeting on Bioanalysis /16./ Datum konání 24.09.2019 - 26.09.2019 Místo konání Gdańsk Země PL - Polsko Typ akce WRD Jazyk dok. eng - angličtina Země vyd. PL - Polsko Klíč. slova dry blood spot ; basic drugs ; DBS technique ; bioanalysis Vědní obor RIV CB - Analytická chemie, separace Obor OECD Analytical chemistry CEP GA18-13135S GA ČR - Grantová agentura ČR Institucionální podpora UIACH-O - RVO:68081715 Anotace In the actual contribution, a simple process was developed and optimized for effective IS addition and DBS elution. A group of acidic and/or basic drugs, with different chemical characteristics, was added to the collected capillary blood in different ways and the mixture was transferred onto the DBS collection card (903®Whatman™). Various elution procedures were also examined and are discussed. Direct injection of the eluted DBS sample into CE-UV ensured a rapid and reliable determination of the drugs without the need for any additional pretreatment steps (extraction, preconcentration). The contents of analytes in the dissolved eluates were determined and recoveries >70% were achieved for the optimized elution systems with satisfactory repeatability (RSD <5%). Pracoviště Ústav analytické chemie Kontakt Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Rok sběru 2020
Počet záznamů: 1