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Effect of hyperbaric air on endotoxin from Bacteroides fragilis strains
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SYSNO ASEP 0481405 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Effect of hyperbaric air on endotoxin from Bacteroides fragilis strains Tvůrce(i) Chmelař, D. (CZ)
Kašíková, A. (CZ)
Martineková, P. (CZ)
Hájek, M. (CZ)
Rozložník, M. (CZ)
Brabec, Marek (UIVT-O) RID, SAI, ORCID
Janečková, J. (CZ)
Vobejdová, J. (CZ)
Čižnár, I. (SK)Zdroj.dok. Folia Microbiologica. - : Springer - ISSN 0015-5632
Roč. 63, č. 3 (2018), s. 283-290Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova endotoxin ; hyperbaric condition Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology Institucionální podpora UIVT-O - RVO:67985807 UT WOS 000430317100003 EID SCOPUS 85033576347 DOI https://doi.org/10.1007/s12223-017-0564-1 Anotace The aim of the project was to determine any effect of hyperbaric air on Bacteroides fragilis strains cultivated under hyperbaric conditions. Previously, it was hypothesized that there was a correlation between the presence of Bacteroides bacteria in patients preferring a meaty diet and cancer of the small intestine, and particularly of the large intestine and rectum. With respect to the fact that Bacteroides fragilis (BAFR) group are important producers of endotoxins, measurement and statistical evaluation of endotoxin production by individual strains of isolated Bacteroides species were used to compare bacteria isolated from various clinical samples from patients with colon and rectum cancer in comparison with strains isolated from other non-cancer diagnoses. Endotoxin production was proven by quantitative detection using the limulus amebocyte lysate (LAL) test in EU/mL. Production of endotoxins in these bacteria cultured under hyperbaric air conditions was higher than those strains cultured under normobaric anaerobic conditions. But these differences in endotoxin production were not statistically significant (t test with log-transformed data, p value = 0.0910). Based on a two-tier t test for lognormal data, it is possible to cautiously conclude that a statistically significant difference was found between endotoxin production by Bacteroides fragilis strains isolated from non-carcinoma diagnoses (strains (1–6) and strains isolated from colorectal carcinoma diagnoses (strains 7–8, Wilcoxon non-parametric test p = 0.0132, t test = 0.1110, t test with log-transformed data, p value = 0.0294). Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2019
Počet záznamů: 1