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A chromosome conformation capture ordered sequence of the barley genome
- 1.0476487 - ÚEB 2018 RIV GB eng J - Článek v odborném periodiku
Mascher, M. - Gundlach, H. - Himmelbach, A. - Beier, S. - Twardziok, S. O. - Wicker, T. - Šimková, Hana - Staňková, Helena - Vrána, Jan - Chan, S. - Munoz-Amatrian, M. - Houben, A. - Doležel, Jaroslav - Ayling, S. - Lonardi, S. - Mayer, K.F.X. - Zhang, G. - Braumann, I. - Spannagl, M. - Li, C. - Waugh, R. - Stein, N. … celkem 76 autorů
A chromosome conformation capture ordered sequence of the barley genome.
Nature. Roč. 544, č. 7651 (2017), s. 427-433. ISSN 0028-0836. E-ISSN 1476-4687
Grant CEP: GA MŠMT(CZ) LO1204
Institucionální podpora: RVO:61389030
Klíčová slova: bacterial artificial chromosomes * inverted-repeat elements * complex-plant genomes * hi-c * environmental adaptation * ltr retrotransposons * structural variation * maize genome * software * database
Obor OECD: Plant sciences, botany
Impakt faktor: 41.577, rok: 2017
Cereal grasses of the Triticeae tribe have been the major food source in temperate regions since the dawn of agriculture. Their large genomes are characterized by a high content of repetitive elements and large pericentromeric regions that are virtually devoid of meiotic recombination. Here we present a high-quality reference genome assembly for barley (Hordeum vulgare L.). We use chromosome conformation capture mapping to derive the linear order of sequences across the pericentromeric space and to investigate the spatial organization of chromatin in the nucleus at megabase resolution. The composition of genes and repetitive elements differs between distal and proximal regions. Gene family analyses reveal lineage-specific duplications of genes involved in the transport of nutrients to developing seeds and the mobilization of carbohydrates in grains. We demonstrate the importance of the barley reference sequence for breeding by inspecting the genomic partitioning of sequence variation in modern elite germplasm, highlighting regions vulnerable to genetic erosion.
Trvalý link: http://hdl.handle.net/11104/0272975
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