Počet záznamů: 1
Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation
- 1.0475702 - FGÚ 2018 RIV US eng J - Článek v odborném periodiku
Petrovič, Miloš - da Silva, S. V. - Clement, J. P. - Vyklický ml., Ladislav - Mulle, C. - González-González, I. M. - Henley, J. M.
Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation.
Nature Neuroscience. Roč. 20, č. 4 (2017), s. 529-539. ISSN 1097-6256. E-ISSN 1546-1726
Grant CEP: GA ČR(CZ) GA17-02300S
Institucionální podpora: RVO:67985823
Klíčová slova: hippocampus * long-term potentiation * membrane proteins
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 19.912, rok: 2017
Long-term potentiation (LTP) in the rat hippocampus is the most extensively studied cellular model for learning and memory. Induction of classical LTP involves an NMDA-receptor-and calcium-dependent increase in functional synaptic AMPA receptors, mediated by enhanced recycling of internalized AMPA receptors back to the postsynaptic membrane. Here we report a physiologically relevant NMDA-receptor-independent mechanism that drives increased AMPA receptor recycling and LTP. This pathway requires the metabotropic action of kainate receptors and activation of G protein, protein kinase C and phospholipase C. Like classical LTP, kainate-receptor-dependent LTP recruits recycling endosomes to spines, enhances synaptic recycling of AMPA receptors to increase their surface expression and elicits structural changes in spines, including increased growth and maturation. These data reveal a new and, to our knowledge, previously unsuspected role for postsynaptic kainate receptors in the induction of functional and structural plasticity in the hippocampus.
Trvalý link: http://hdl.handle.net/11104/0272353
Počet záznamů: 1