0435790 - ÚMG 2015 RIV GB eng J - Článek v odborném periodiku
Hrdinka, Matouš - Hořejší, Václav
PAG - a multipurpose transmembrane adaptor protein.
Oncogene. Roč. 33, č. 41 (2014), s. 4881-4892. ISSN 0950-9232. E-ISSN 1476-5594
Grant CEP: GA ČR(CZ) GBP302/12/G101
Institucionální podpora: RVO:68378050
Klíčová slova: PAG * adaptor protein * membrane raft
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 8.459, rok: 2014

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), also known as Csk-binding protein (Cbp), is a ubiquitously expressed transmembrane adaptor protein present in lipid rafts and involved in a number of signaling pathways. It helps recruit cytoplasmic C-terminal Src kinase (Csk) to lipid raft-associated Src kinases, mediates a link to actin cytoskeleton and interacts with several other important cytoplasmic and plasma membrane-associated proteins. In recent years, PAG has been implicated in various aspects of cancer cell biology. Our review covers all so far published data on this interesting protein.
Trvalý link: http://hdl.handle.net/11104/0239663