Počet záznamů: 1
Enzymatic Glycosylation of Small Molecules: Challenging Substrates Require Tailored Catalysts
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SYSNO ASEP 0381774 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Enzymatic Glycosylation of Small Molecules: Challenging Substrates Require Tailored Catalysts Tvůrce(i) Desmet, T. (BE)
Soetaert, W. (BE)
Bojarová, Pavla (MBU-M) ORCID
Křen, Vladimír (MBU-M) RID, ORCID
Dijkhuizen, L. (NL)
Eastwick-Field, V. (GB)
Schiller, A. (DE)Zdroj.dok. Chemistry - A European Journal. - : Wiley - ISSN 0947-6539
Roč. 18, č. 35 (2012), s. 10786-10801Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova acceptor specificity ; enzyme engineering ; glycosylation Vědní obor RIV CE - Biochemie Institucionální podpora MBU-M - RVO:61388971 UT WOS 000307782800002 DOI 10.1002/chem.201103069 Anotace Glycosylation can significantly improve the physicochemical and biological properties of small molecules like vitamins, antibiotics, flavors, and fragrances. The chemical synthesis of glycosides is, however, far from trivial and involves multistep routes that generate lots of waste. In this review, biocatalytic alternatives are presented that offer both stricter specificities and higher yields. The advantages and disadvantages of different enzyme classes are discussed and illustrated with a number of recent examples. Progress in the field of enzyme engineering and screening are expected to result in new applications of biocatalytic glycosylation reactions in various industrial sectors Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2013
Počet záznamů: 1