Počet záznamů: 1
A new type of irreversibly reductively biodegradable hydrogel
- 1.0359453 - ÚMCH 2012 RIV NL eng J - Článek v odborném periodiku
Vetrík, Miroslav - Hrubý, Martin - Přádný, Martin - Michálek, Jiří
A new type of irreversibly reductively biodegradable hydrogel.
Polymer Degradation and Stability. Roč. 96, č. 5 (2011), s. 892-897. ISSN 0141-3910. E-ISSN 1873-2321
Grant CEP: GA ČR GAP108/10/1560; GA ČR GPP207/10/P054; GA MŠMT 1M0538
Výzkumný záměr: CEZ:AV0Z40500505
Klíčová slova: biodegradable hydrogel * disulfide * L-cysteine
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 2.769, rok: 2011
Reductively biodegradable hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with N-[3-(methacryloylamino)propyl] -6-{[5-({[3-(methacryloylamino)propyl]amino}carbonyl)-2-pyridyl]disulfanyl}nicotinamide intended for tissue engineering were synthesized and characterized. The rate of irreversible reductive degradation with thiol l-cysteine (a model of human body where several thiols are present in extracellular space) was studied using several l-cysteine concentrations. The mechanism of the irreversible reductive bond cleavage in the crosslinker structure was confirmed on a low-molecular-weight model. The hydrogel is stable during storage in phosphate buffered saline and is degraded relatively quickly in a concentration-dependent manner after addition of l-cysteine to the surrounding medium.
Trvalý link: http://hdl.handle.net/11104/0197239
Počet záznamů: 1