Počet záznamů: 1
Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling
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SYSNO ASEP 0347137 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling Tvůrce(i) Hubáčková, Soňa (UMG-J) RID
Nováková, Zora (UMG-J)
Krejčíková, Kateřina (UMG-J)
Košař, Martin (UMG-J)
Dobrovolná, Jana (UMG-J) RID
Dušková, Pavlína (UMG-J)
Hanzlíková, Hana (UMG-J) RID
Vančurová, Markéta (UMG-J)
Barath, P. (SE)
Bartek, J. (DK)
Hodný, Zdeněk (UMG-J) RIDZdroj.dok. Cell Cycle. - : Taylor & Francis - ISSN 1538-4101
Roč. 9, č. 15 (2010), s. 3085-3099Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova PML tumor suppressor ; cellular senescence ; JAK-STAT signaling pathway Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA500390501 GA AV ČR - Akademie věd GA204/08/1418 GA ČR - Grantová agentura ČR GA301/08/0353 GA ČR - Grantová agentura ČR CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000281206300038 DOI 10.4161/cc.9.15.12521 Anotace PML tumor suppressor is upregulated in several forms of cellular senescence, however the mechanism of its induction is elusive. Here we show that genotoxic drugs that induce senescence, such as bromodeoxyuridine, thymidine, distamycin A, aphidicolin, etoposide and camptothecin evoke expansion of PML nuclear compartment and its association with persistent DNA lesions in several human normal and cancer cells. This phenomenon was accompanied by elevation of PML transcripts. Chemical inhibition of all JAK kinases and RNAi-mediated knock-down of JAK1 suppressed PML expression, implicating JAK/STAT-mediated signaling in regulation of the PML gene. Our data show that upregulation of the PML tumor suppressor in cellular senescence triggered by diverse drugs including clinically used anti-cancer chemotherapeutics relies on stimulation of PML transcription by JAK/STAT-mediated signaling, possibly evoked by the autocrine/paracrine activities of senescence-associated cytokines. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2011
Počet záznamů: 1