Počet záznamů: 1
Olfactory Dysfunction in Narcolepsy with and without Cataplexy
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SYSNO ASEP 0343526 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Olfactory Dysfunction in Narcolepsy with and without Cataplexy Tvůrce(i) Bušková, J. (CZ)
Klaschka, Jan (UIVT-O) RID, SAI, ORCID
Šonka, K. (CZ)
Nevšímalová, S. (CZ)Zdroj.dok. Sleep Medicine. - : Elsevier - ISSN 1389-9457
Roč. 11, č. 6 (2010), s. 558-561Poč.str. 4 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova narcolepsy ; cataplexy ; narcolepsy without cataplexy ; RBD ; olfactory dysfunction Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEZ AV0Z10300504 - UIVT-O (2005-2011) UT WOS 000279424800010 EID SCOPUS 77953359910 DOI 10.1016/j.sleep.2010.01.009 Anotace Not only patients in whom REM behavior disorder (RBD) is associated with narcolepsy, but also those with narcolepsy alone are reported to have olfactory dysfunction. We investigated if hyposmia is specific to narcolepsy with cataplexy (N-C) or if narcolepsy without cataplexy (NwC) is also associated with olfactory dysfunction. We studied olfactory function in two groups of patients: N-C group (n = 66), and NwC group (n = 17). As a control group we used published normative data for particular smell tests. Both patients with N-C and NwC had a significantly higher olfactory threshold and impaired odor identification. Our results show for the first time that narcolepsy without cataplexy, where the majority of cases have normal CSF hypocretin levels, is associated with olfactory dysfunction. It appears that also a partial loss of hypothalamic hypocretin neurons without a clear CSF level decrease can affect smell projection. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2011
Počet záznamů: 1