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A semisynthetic 5-n-alkylresoreinol derivative and its effect upon biomemhrane properties
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SYSNO ASEP 0309648 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title A semisynthetic 5-n-alkylresoreinol derivative and its effect upon biomemhrane properties Title Deriváty semisyntetického 5-n-alkylresoreinolu a jeho biomembránové vlastnosti Author(s) Stasiuk, M. (PL)
Bartosiewicz, D. (PL)
Gubernator, J. (PL)
Cieslik-Boczula, K. (PL)
Hof, Martin (UFCH-W) RID, ORCID
Kozubek, A. (PL)Source Title Zeitschrift fuer Naturforschung. Section C: a Journal of Biosciences. - : Walter de Gruyter - ISSN 0939-5075
Roč. 62, 11-12 (2007), s. 881-888Number of pages 8 s. Language eng - English Country DE - Germany Keywords phenolic lipids ; hemolytic activity ; phospholipase A2 ; acetylcholinesterase Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects 1ET400400413 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40400503 - UFCH-W (2005-2011) Annotation MSAR (1-sulfate-3-myristoyl-5-pentadecylbenzene) is a semisynthetic derivative of 5-n-pentadecylresorcinol (C15:0). MSAR exhibits hemolytic activity against sheep erythrocytes with a EH50 value of (35 +/- 1.7) mu M. At low concentrations MSAR also exhibits the ability to protect cells against their hypoosmotic lysis. This protective effect is significant as, at 0.1 mu M of MSAR, the extent of osmotically induced cell lysis is reduced by approx. 20%. It was demonstrated that the 9-anthroyloxystearic acid signal was most intensively quenched by MSAR molecules, suggesting a relatively deep location of these molecules within the lipid bilayer. MSAR causes an increase of the fluorescence of the membrane potential sensitive probe. This indicates an alteration of the surface charge and a decrease of the local pH value at the membrane surface. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2008
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