0194569 - UOCHB-X 20020240 RIV US eng J - Článek v odborném periodiku
Balzarini, J. - Pannecouque, C. - De Clercq, E. - Aquaro, S. - Perno, C. F. - Egberink, H. - Holý, Antonín
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates.
Antimicrobial Agents and Chemotherapy. Roč. 46, č. 7 (2002), s. 2185-2193. ISSN 0066-4804. E-ISSN 1098-6596
Grant CEP: GA ČR GV203/96/K001
Výzkumný záměr: CEZ:AV0Z4055905
Klíčová slova: nucleoside phosphonates
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 4.215, rok: 2002

Anovel class of acyclic nucleoside phosphonates has been discovered in which the base consists of a pyrimidine preferably containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy) ethoxy (PMEO) or a 2-(phosphonomethoxy)propoxy (PMPO) group at C-6. The 6-PMEO 2,4-diaminopyrimidine and 6-PMPO 2,4-diaminopyrimidine derivatives showed potent activity HIV.
Trvalý link: http://hdl.handle.net/11104/0090244