The changes in mammary, uterine and seminal vesicle growth were intended to identify the in vivo activity of estrogen antagonists. Using the combinations of hormone agonist and antagonist, we tested and compared four models systems, the young intact and adult gonadectomized male and female mice. Steroidal antiestrogen (ICI) always behaved as an antiestrogen: ICI alone or in combination with estradiol (E) or progesterone (Prog) decreased mammary and uterine growth in prepubertal and adult ovariectomized (OV-X) females and decreased mammary growth in prepubertal and adult castrated males treated with E. In prepubertal males ICI alone or in combination with Prog or E also increased seminal vesicle weights. Nonsteroidal antiestrogen EM-800 (EM) alone had no effect on mammary and uterine growth in prepubertal females, and in adult OV-X females uterine growth was even stimulated by EM alone, and a combination of EM plus Prog stimulated not only uterine growth but also mam,ary growth.
Pracoviště
Ústav živočišné fyziologie a genetiky
Kontakt
Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Rok sběru
2006
Počet záznamů: 1
openseadragon
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