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Perineuronal nets affect memory and learning after synapse withdrawal
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SYSNO ASEP 0566603 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Perineuronal nets affect memory and learning after synapse withdrawal Tvůrce(i) Růžička, Jiří (UEM-P)
Dalecká, L. (CZ)
Šafránková, Kristýna (UEM-P)
Peretti, D. (GB)
Jendelová, Pavla (UEM-P) RID, ORCID
Kwok, Jessica (UEM-P) ORCID, RID
Fawcett, James (UEM-P) ORCIDČíslo článku 480 Zdroj.dok. Translational Psychiatry . - : Springer - ISSN 2158-3188
Roč. 12, č. 1 (2022)Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova conditioned place preference ; prefrontal cortex impairs ; extracellular-matrix ; chondroitin sulfate ; restores memory ; plasticity Obor OECD Neurosciences (including psychophysiology CEP EF15_003/0000419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA19-10365S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000884275600001 EID SCOPUS 85141821623 DOI 10.1038/s41398-022-02226-z Anotace Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed that the cavities in PNNs, which contain synapses, can act as a memory store and that they remain stable after events that cause synaptic withdrawal such as anoxia or hibernation. We examine this idea by monitoring place memory before and after synaptic withdrawal caused by acute hibernation-like state (HLS). Animals lacking hippocampal PNNs due to enzymatic digestion by chondroitinase ABC or knockout of the PNN component aggrecan were compared with wild type controls. HLS-induced synapse withdrawal caused a memory deficit, but not to the level of untreated naive animals and not worsened by PNN attenuation. After HLS, only animals lacking PNNs showed memory restoration or relearning. Absence of PNNs affected the restoration of excitatory synapses on PNN-bearing neurons. The results support a role for hippocampal PNNs in learning, but not in long-term memory storage for correction of deficits. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2023 Elektronická adresa https://www.nature.com/articles/s41398-022-02226-z
Počet záznamů: 1