Počet záznamů: 1
Modulation of differentiation of embryonic stem cells by polypyrrole: the impact on neurogenesis
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SYSNO ASEP 0537040 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Modulation of differentiation of embryonic stem cells by polypyrrole: the impact on neurogenesis Tvůrce(i) Skopalová, K. (CZ)
Radaszkiewicz, K. A. (CZ)
Kašpárková, V. (CZ)
Stejskal, Jaroslav (UMCH-V) RID, ORCID, SAI
Bober, Patrycja (UMCH-V) RID, ORCID, SAI
Junkar, I. (SI)
Mozetič, M. (SI)
Capáková, Z. (CZ)
Lehocký, M. (CZ)
Kašparová, M. (CZ)
Pacherník, J. (CZ)
Humpolíček, P. (CZ)Číslo článku 501 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 22, č. 2 (2021)Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova conducting polymer ; polypyrrole ; biocompatibility Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000611321200001 EID SCOPUS 85099135097 DOI 10.3390/ijms22020501 Anotace The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells. This finding ledto an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecular-weight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy. The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/1422-0067/22/2/501
Počet záznamů: 1