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The silent information regulator 1 (Sirt1) is a positive regulator of the Notch pathway in Drosophila
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SYSNO ASEP 0465215 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The silent information regulator 1 (Sirt1) is a positive regulator of the Notch pathway in Drosophila Tvůrce(i) Horváth, Matěj (BC-A)
Mihajlović, Zorana (BC-A)
Slaninová, Věra (BC-A)
Perez-Gomez, Raquel (BC-A) RID, ORCID
Moshkin, Y. (RU)
Krejčí, Alena (BC-A) RID, ORCIDCelkový počet autorů 6 Zdroj.dok. Biochemical Journal. - : Portland Press - ISSN 0264-6021
Roč. 473, č. 22 (2016), s. 4129-4143Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Drosophila ; silent information regulator 1 ; Notch pathway Vědní obor RIV EB - Genetika a molekulární biologie CEP GA14-08583S GA ČR - Grantová agentura ČR Institucionální podpora BC-A - RVO:60077344 UT WOS 000393759300004 EID SCOPUS 85009516150 DOI 10.1042/BCJ20160563 Anotace The silent information regulator 1 (Sirt1) has previously been shown to have negative effects on the Notch pathway in several contexts. We bring evidence that Sirt1 has a positive effect on Notch activation in Drosophila, in the context of sensory organ precursor specification and during wing development. The phenotype of Sirt1 mutant resembles weak Notch loss of function phenotypes and genetic interactions of Sirt1 with the components of the Notch pathway also suggest a positive role of Sirt1 in Notch signalling. Sirt1 is necessary for the efficient activation of E(spl) genes by Notch in S2N cells. Additionally, the Notch dependent response of several E(spl) genes is sensitive to metabolic stress caused by 2-deoxyglucose treatment, in a Sirt1 dependent manner. We found Sirt1 associated with several proteins involved in Notch repression as well as activation, including the cofactor exchange factor ebi (TBL1), the RLAF/LAF histone chaperon complex and the Tip60 acetylation complex. Moreover, Sirt1 participates in the deacetylation of the CSL transcription factor Su(H). The role of Sirt1 in Notch signalling is therefore more complex than previously recognised and its diverse effects may be explained by a plethora of Sirt1 substrates involved in the regulation of Notch signalling.
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