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POCl.sub.3./sub. mediated one-pot deoxygenative aromatization and electrophilic chlorination of dihydroxy-2-methyl-4-oxo-indeno[1,2-b]pyrroles
- 1.0573800 - FZÚ 2024 RIV GB eng J - Článek v odborném periodiku
Nasuhipur, A. - Ghasemi, Z. - Poupon, Morgane - Dušek, Michal
POCl3 mediated one-pot deoxygenative aromatization and electrophilic chlorination of dihydroxy-2-methyl-4-oxo-indeno[1,2-b]pyrroles.
RSC Advances. Roč. 13, č. 26 (2023), s. 17812-17816. ISSN 2046-2069. E-ISSN 2046-2069
Grant CEP: GA MŠMT(CZ) LM2018096
Institucionální podpora: RVO:68378271
Klíčová slova: indenopyrroles * vicinal hydroxyl group * crystal structure * X-ray diffraction
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 3.9, rok: 2023
Způsob publikování: Open access
A class of indenopyrroles is presented by the treatment of known dihydroxy-2-methyl-4-oxoindeno[1,2-b] pyrroles with phosphorus oxychloride (POCl3). The elimination of vicinal hydroxyl groups at the 3a and 8b positions, formation of a p bond, and electrophilic chlorination of the methyl group attached to C2 resulted in the fused aromatic pyrrole structures. Benzylic substitution of various nucleophiles such as H2O, EtOH, and NaN3 with a chlorine atom gave diverse 4-oxoindeno[1,2-b]pyrrole derivatives in 58 to 93% yields. The reaction was investigated in different aprotic solvents, and the highest reaction yield was obtained in DMF. The structures of the products were confirmed by spectroscopic methods, elemental analysis, and X-ray crystallography.
Trvalý link: https://hdl.handle.net/11104/0344159
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