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Size-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis
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SYSNO ASEP 0564362 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Size-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis Tvůrce(i) Libánská, Alena (UMCH-V) RID, ORCID
Randárová, Eva (UMCH-V) RID
Skoroplyas, Svitlana (BFU-R)
Bartoš, M. (CZ)
Luňáčková, J. (CZ)
Lager, F. (FR)
Renault, G. (FR)
Scherman, D. (FR)
Etrych, Tomáš (UMCH-V) RID, ORCIDZdroj.dok. Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 353, January (2023), s. 30-41Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova polymer conjugate ; drug delivery ; inflammation Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Vědní obor RIV – spolupráce Biofyzikální ústav - Biofyzika CEP NU20-08-00255 GA MZd - Ministerstvo zdravotnictví GJ19-00956Y GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 ; BFU-R - RVO:68081707 UT WOS 000898783400002 EID SCOPUS 85142324204 DOI 10.1016/j.jconrel.2022.11.027 Anotace Chronic inflammatory diseases such as rheumatoid arthritis represent a substantial socio-economic impact and have a high prevalence in the modern world. Nano-sized polymer therapeutics have shown suitable characteristics for becoming the next generation of anti-inflammatory nanomedicines. Here, we present biocompatible and stimuli-sensitive N-(2-hydroxypropyl)methacrylamide based polymer conjugates with the anti-inflammatory drug dexamethasone (DEX), which has been tailored for prolonged blood circulation, enhanced inflammatory site accumulation, site-specific drug release and subsequent elimination of the carrier via urine excretion. The hydrodynamic size of novel polymer-DEX nanomedicine was adjusted to prolong its blood circulation whilst maintaining the renal excretability of the polymer carrier after drug release in inflamed tissue. The therapeutic efficacy of the studied polymer nanomedicines was evaluated in a model of dissipated chronic arthritis, i.e. collagen II-induced arthritis, in mice. The pH-sensitive drug attachment enabled enhanced blood circulation with minimal systemic drug release, as well as rapid drug activation in affected joints. Importantly, unlike free DEX, the polymer nanomedicines were able to diminish joint inflammation and arthritis-induced bone damage - even at a reduced dosing regimen - as evaluated by micro computed tomography (micro-CT). Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0168365922007726?via%3Dihub
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