Počet záznamů: 1  

Size-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis

  1. 1.
    SYSNO ASEP0564362
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevSize-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis
    Tvůrce(i) Libánská, Alena (UMCH-V) RID, ORCID
    Randárová, Eva (UMCH-V) RID
    Skoroplyas, Svitlana (BFU-R)
    Bartoš, M. (CZ)
    Luňáčková, J. (CZ)
    Lager, F. (FR)
    Renault, G. (FR)
    Scherman, D. (FR)
    Etrych, Tomáš (UMCH-V) RID, ORCID
    Zdroj.dok.Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
    Roč. 353, January (2023), s. 30-41
    Poč.str.12 s.
    Jazyk dok.eng - angličtina
    Země vyd.NL - Nizozemsko
    Klíč. slovapolymer conjugate ; drug delivery ; inflammation
    Vědní obor RIVCD - Makromolekulární chemie
    Obor OECDPolymer science
    Vědní obor RIV – spolupráceBiofyzikální ústav - Biofyzika
    CEPNU20-08-00255 GA MZd - Ministerstvo zdravotnictví
    GJ19-00956Y GA ČR - Grantová agentura ČR
    Způsob publikováníOmezený přístup
    Institucionální podporaUMCH-V - RVO:61389013 ; BFU-R - RVO:68081707
    UT WOS000898783400002
    EID SCOPUS85142324204
    DOI10.1016/j.jconrel.2022.11.027
    AnotaceChronic inflammatory diseases such as rheumatoid arthritis represent a substantial socio-economic impact and have a high prevalence in the modern world. Nano-sized polymer therapeutics have shown suitable characteristics for becoming the next generation of anti-inflammatory nanomedicines. Here, we present biocompatible and stimuli-sensitive N-(2-hydroxypropyl)methacrylamide based polymer conjugates with the anti-inflammatory drug dexamethasone (DEX), which has been tailored for prolonged blood circulation, enhanced inflammatory site accumulation, site-specific drug release and subsequent elimination of the carrier via urine excretion. The hydrodynamic size of novel polymer-DEX nanomedicine was adjusted to prolong its blood circulation whilst maintaining the renal excretability of the polymer carrier after drug release in inflamed tissue. The therapeutic efficacy of the studied polymer nanomedicines was evaluated in a model of dissipated chronic arthritis, i.e. collagen II-induced arthritis, in mice. The pH-sensitive drug attachment enabled enhanced blood circulation with minimal systemic drug release, as well as rapid drug activation in affected joints. Importantly, unlike free DEX, the polymer nanomedicines were able to diminish joint inflammation and arthritis-induced bone damage - even at a reduced dosing regimen - as evaluated by micro computed tomography (micro-CT).
    PracovištěÚstav makromolekulární chemie
    KontaktEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Rok sběru2024
    Elektronická adresahttps://www.sciencedirect.com/science/article/pii/S0168365922007726?via%3Dihub
Počet záznamů: 1  

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