Počet záznamů: 1
Biopolymer strategy for the treatment of Wilson´s disease
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SYSNO ASEP 0486034 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Biopolymer strategy for the treatment of Wilson´s disease Tvůrce(i) Vetrík, Miroslav (UMCH-V) RID, ORCID
Mattová, J. (CZ)
Macková, Hana (UMCH-V) RID
Kučka, Jan (UMCH-V) RID, ORCID
Poučková, P. (CZ)
Kukačková, Olivia (UMCH-V) RID
Brus, Jiří (UMCH-V) RID, ORCID
Eigner-Henke, S. (CZ)
Sedláček, Ondřej (UMCH-V) RID, ORCID
Šefc, L. (CZ)
Štěpánek, Petr (UMCH-V) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCIDZdroj.dok. Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 273, 10 March (2018), s. 131-138Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Wilson's disease ; copper chelators ; biopolymers Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GA16-02870S GA ČR - Grantová agentura ČR NV15-25781A GA MZd - Ministerstvo zdravotnictví LM2015064 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LO1507 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000426298100011 EID SCOPUS 85041427052 DOI 10.1016/j.jconrel.2018.01.026 Anotace Wilson's disease is a genetic disorder that causes excessive accumulation of copper in the body, leading to toxic damage, especially in the liver and nervous system. The current treatment cause burdensome side effects. We describe the use of chemically modified biopolymer carriers based on microcrystalline cellulose and chitosan containing the highly specific copper chelator 8-hydroxyquinoline as a new type of therapy for Wilson's disease. The chelators can scavenges copper ions released from food during digestion and copper ions present in secretions in the gastrointestinal tract. Because the chelator is covalently bound to indigestible biopolymer carriers (crosslinked chitosan or modified cellulose), it is not taken up by the gastrointestinal tract and it can be eliminated through the feces, avoiding unwanted side effects. This concept was tested on Wistar rats, which received a radioactive 64CuCl2 solution together with the polymers with covalently bound 8-hydroxyquinoline through a gastric probe. 64Copper complex uptake from the gastrointestinal tract was significantly inhibited by both chelating polymers. With the modified polymers, the presence of 64Cu was detected mostly in the gastrointestinal tract, not in the internal organs. These findings indicate modified cellulose and crosslinked chitosan, with covalently bound 8-hydroxyquinoline exhibited the potential to be excellent therapeutics for treating Wilson's disease.
Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2019
Počet záznamů: 1