Počet záznamů: 1
Phosphanucleosides containing 1-hydroxymethylphospholane 1-oxide ring
- 1.0429024 - ÚOCHB 2015 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Páv, Ondřej - Zborníková, Eva - Buděšínský, Miloš - Rosenberg, Ivan
Phosphanucleosides containing 1-hydroxymethylphospholane 1-oxide ring.
Chemistry of Nucleic Acid Components. 16th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2014 - (Hocek, M.), s. 344-345. Collection Symposium Series, 14. ISBN 978-80-86241-50-0.
[Symposium on Chemistry of Nucleic Acid Components /16./. Český Krumlov (CZ), 08.06.2014-13.06.2014]
Grant CEP: GA ČR GA13-26526S; GA ČR GA13-24880S; GA TA ČR TA03010598
Institucionální podpora: RVO:61388963
Klíčová slova: phosphanucleosides * 1-hydroxymethylphospholane 1-oxide ring * biological activity
Kód oboru RIV: CC - Organická chemie
Novel phosphanucleosides containing 1-hydroxymethylphospholane 1-oxide ring were synthesized as compounds with potential biological activity. A ring-closing metathesis was employed to prepare a phospholene precursor, which was then converted into either 4-azido-3-hydroxy-1-hydroxymethylphospholane 1-oxide or 3-azido-1- hydroxymethylphospholane 1-oxide derivatives. Subsequently, nucleobase was introduced using a nucleobase construction. The biological activity of prepared compounds was evaluated.
Trvalý link: http://hdl.handle.net/11104/0234439
Počet záznamů: 1