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Heteromorphic ZZ/ZW sex chromosomes sharing gene content with mammalian XX/XY are conserved in Madagascan chameleons of the genus iFurcifer/i
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SYSNO ASEP 0585092 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Heteromorphic ZZ/ZW sex chromosomes sharing gene content with mammalian XX/XY are conserved in Madagascan chameleons of the genus iFurcifer/i Tvůrce(i) Rovatsos, M. (CZ)
Mazzoleni, S. (CZ)
Augstenová, B. (CZ)
Altmanová, Marie (UZFG-Y) ORCID
Velenský, P. (CZ)
Glaw, F. (DE)
Sánchez, A. (ES)
Kratochvíl, L. (CZ)Celkový počet autorů 8 Číslo článku 4898 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 14, č. 1 (2024)Poč.str. 10 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Homology ; Karyotypes ; Microdissection ; Sex chromosomes ; qPCR ; Chameleons Obor OECD Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 001178172300011 EID SCOPUS 85186186332 DOI 10.1038/s41598-024-55431-9 Anotace Chameleons are well-known lizards with unique morphology and physiology, but their sex determination has remained poorly studied. Madagascan chameleons of the genus Furcifer have cytogenetically distinct Z and W sex chromosomes and occasionally Z(1)Z(1)Z(2)Z(2)/Z(1)Z(2)W multiple neo-sex chromosomes. To identify the gene content of their sex chromosomes, we microdissected and sequenced the sex chromosomes of F. oustaleti (ZZ/ZW) and F. pardalis (Z(1)Z(1)Z(2)Z(2)/Z(1)Z(2)W). In addition, we sequenced the genomes of a male and a female of F. lateralis (ZZ/ZW) and F. pardalis and performed a comparative coverage analysis between the sexes. Despite the notable heteromorphy and distinctiveness in heterochromatin content, the Z and W sex chromosomes share approximately 90% of their gene content. This finding demonstrates poor correlation of the degree of differentiation of sex chromosomes at the cytogenetic and gene level. The test of homology based on the comparison of gene copy number variation revealed that female heterogamety with differentiated sex chromosomes remained stable in the genus Furcifer for at least 20 million years. These chameleons co-opted for the role of sex chromosomes the same genomic region as viviparous mammals, lacertids and geckos of the genus Paroedura, which makes these groups excellent model for studies of convergent and divergent evolution of sex chromosomes. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2025 Elektronická adresa https://www.nature.com/articles/s41598-024-55431-9
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