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Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth
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SYSNO ASEP 0537924 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth Tvůrce(i) Kasálková-Slepičková, N. (CZ)
Slepička, P. (CZ)
Ivanovská, B. (CZ)
Trávníčková, Martina (FGU-C) RID, ORCID, SAI
Malinský, Petr (UJF-V) RID, ORCID, SAI
Macková, Anna (UJF-V) RID, ORCID, SAI
Bačáková, Lucie (FGU-C) RID, ORCID
Švorčík, V. (CZ)Číslo článku 1083 Zdroj.dok. Coatings. - : MDPI - ISSN 2079-6412
Roč. 10, č. 11 (2020)Poč.str. 20 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova cytocompatibility ; nanoparticle doping ; plasma treatment ; polymer ; PVA ; surface characterization ; tissue engineering Vědní obor RIV EI - Biotechnologie a bionika Obor OECD Biomaterials (as related to medical implants, devices, sensors) Vědní obor RIV – spolupráce Ústav jaderné fyziky - Jaderná, atomová a mol. fyzika, urychlovače CEP GA19-02482S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 ; UJF-V - RVO:61389005 UT WOS 000592729900001 DOI https://doi.org/10.3390/coatings10111083 Anotace Hydrogels, and not only natural polysaccharide hydrogels, are substances capable of absorbing large amounts of water and physiological fluids. In this study, we set out to optimize the process for preparing polyvinyl alcohol (PVA) hydrogels. Subsequently, we doped PVA foils with cellulose powder, with poly(ethylene glycol) (PEG) or with gold nanoparticles in PEG colloid solutions (Au). The foils were then modified in a plasma discharge to improve their biocompatibility. The properties of PVA foils were studied by various analytical methods. The use of a suitable dopant can significantly affect the surface wettability, the roughness, the morphology and the mechanical properties of the material. Plasma treatment of PVA leads to ultraviolet light-induced crosslinking and decreasing water absorption. At the same time, this treatment significantly improves the cytocompatibility of the polymer, which is manifested by enhanced growth of human adipose-derived stem cells. This positive effect on the cell behavior was most pronounced on PVA foils doped with PEG or with Au. This modification of PVA therefore seems to be most suitable for the use of this polymer as a cell carrier for tissue engineering, wound healing and other regenerative applications. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2021 Elektronická adresa https://www.mdpi.com/2079-6412/10/11/1083
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