0431978 - ÚPT 2015 RIV CA eng J - Článek v odborném periodiku
Meluzín, J. - Hude, P. - Leinveber, P. - Jurák, Pavel - Soukup, L. - Viščor, Ivo - Špinarová, L. - Štěpánová, R. - Podroužková, H. - Vondra, Vlastimil - Langer, P. - Němec, P.
The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction.
Experimental and Clinical Cardiology. Roč. 20, č. 1 (2014), s. 674-687. ISSN 1205-6626
Grant CEP: GA MŠMT(CZ) LO1212
Klíčová slova: heart failure * stroke volume index * exercise tolerance * bioimpedance
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 0.758, rok: 2013

Objectives: There is a large variability of exerciseinduced stroke volume behavior in healthy subjects. We sought to assess the course of exercise-induced changes in stroke volume index (SVI) and other functional parameters in post-heart transplant patients with heart failure and normal left ventricular ejection fraction (HFNEF). Methods: Left ventricular function and systemic hemodynamics were assessed at 40 s intervals during the exercise in 39 patients using simultaneous right heart catheterization, bioimpedance, and echocardiography. Results: Twenty-six patients had exercise tolerance ≥ 4.0 METs (Group A), while 13 patients exhibited severely limited exercise tolerance < 4 METs (Group B). Maximal SVI (maxSVI) achieved at any time during the exercise exceeded SVI at peak exercise (peakSVI) in 26 patients (67%). Both maxSVI and delta_maxSVI (maxSVI minus SVI at rest) were significantly higher in Group A compared to Group B patients (59 ml/m2 vs 41 ml/m2, p < 0.01, and 21 ml/m2 vs 6 ml/m2, p < 0.01, respectively). With peakSVI, maxSVI, delta_peakSVI, delta_maxSVI and other variables evaluated, only delta_maxSVI was independently associated with exercise tolerance. Conclusion: When assessing exercise-induced SVI changes in HFNEF patients, SVI should be followed during the course of exercise and maximal SVI change from rest should always be determined.
Trvalý link: http://hdl.handle.net/11104/0236485