There Is No Simple Model of the Plasma Membrane Organization

0463189 - ÚFCH JH 2017 RIV CH eng J - Článek v odborném periodiku
de la Serna, J. B. - Schütz, G. - Eggeling, Ch. - Cebecauer, Marek
There Is No Simple Model of the Plasma Membrane Organization.
Frontiers in Cell and Developmental Biology. Roč. 4, SEP 2016 (2016), s. 106. ISSN 2296-634X. E-ISSN 2296-634X
Grant CEP: GA ČR GA15-06989S
Institucionální podpora: RVO:61388955
Klíčová slova: plasma membrane * membrane organization models * heterogeneous distribution
Obor OECD: Cell biology

Ever since technologies enabled the characterization of eukaryotic plasma membranes, heterogeneities in the distributions of its constituents were observed. Over the years this led to the proposal of various models describing the plasma membrane organization such as lipid shells, picket-and-fences, lipid rafts, or protein islands, as addressed in numerous publications and reviews. Instead of emphasizing on one model we in this review give a brief overview over current models and highlight how current experimental work in one or the other way do not support the existence of a single overarching model. Instead, we highlight the vast variety of membrane properties and components, their influences and impacts. We believe that highlighting such controversial discoveries will stimulate unbiased research on plasma membrane organization and functionality, leading to a better understanding of this essential cellular structure.
Trvalý link: http://hdl.handle.net/11104/0262437