Molecular characterization of alcohol–ether extract from bovine tissue

0545566 - ÚOCHB 2022 RIV CZ eng J - Článek v odborném periodiku
Kubelková, K. - Hubálek, Martin - Řehulka, P. - Řehulková, H. - Friedecký, D. - Žáková, J. - Macela, A.
Molecular characterization of alcohol–ether extract from bovine tissue.
Military Medical Science Letters. Roč. 90, č. 3 (2021), s. 120-136. ISSN 0372-7025. E-ISSN 2571-113X
Institucionální podpora: RVO:61388963
Klíčová slova: bovine tissue extract * Juvenil * molecular composition * psychobiotics * biological response modifier * antimicrobial peptides * defensin * hemocidin
Obor OECD: Analytical chemistry
Způsob publikování: Open access
http://doi.org/10.31482/mmsl.2021.012

It is usual for information to be unavailable regarding the molecular composition of extracts from herbs or animal tissues that are popular in folk medicine. Here, we present analysis of the alcohol–ether extract from bovine tissue analogous to the basic substance used in such commercial products as Retisin, Imuregen, Actovegin, and Solcoseryl. The tested extract contains a whole spectrum of free amino acids, small proteins and oligopeptides of molecular weight up to 10 kDa, various nucleotides, and a small amount of phospholipids. Among the molecules that can explain some biological activities of the extract were identified those of taurine (2-aminoethanesulfonic acid, a derivative of the amino acid cysteine), several defensins, and bactericidal hemoglobin fragments known as hemocidins. All those molecules identified are natural components of bovine tissues, and a substantial number of them might be biologically active in vivo. Others are sources of readily available nutrients.
Trvalý link: http://hdl.handle.net/11104/0322253