Počet záznamů: 1  

Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy

  1. 1.
    0542465 - MBÚ 2022 RIV US eng J - Článek v odborném periodiku
    Breinlinger, S. - Phillips, T. J. - Haram, B. N. - Mareš, Jan - Yerena, J. A. M. - Hrouzek, Pavel - Sobotka, Roman - Henderson, W. M. - Schmieder, P. - Williams, S. M. - Lauderdale, J. D. - Wilde, H. D. - Gerrin, W. - Kust, A. - Washington, J. W. - Wagner, C. - Geier, B. - Liebeke, M. - Enke, H. - Niedermeyer, T. H. J. - Wilde, S. B.
    Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy.
    Science. Roč. 371, č. 6536 (2021), č. článku 1335. ISSN 0036-8075. E-ISSN 1095-9203
    Grant CEP: GA ČR(CZ) GC19-21649J
    Institucionální podpora: RVO:61388971
    Klíčová slova: eagle * cyanobacterial neurotoxin * vacuolar myelinopathy
    Obor OECD: Microbiology
    Impakt faktor: 63.832, rok: 2021
    Způsob publikování: Open access
    Web výsledku:
    https://science.sciencemag.org/content/371/6536/eaax9050.abstract
    DOI: https://doi.org/10.1126/science.aax9050

    Vacuolar myelinopathy is a fatal neurological disease that was initially discovered during a mysterious mass mortality of bald eagles in Arkansas in the United States. The cause of this wildlife disease has eluded scientists for decades while its occurrence has continued to spread throughout freshwater reservoirs in the southeastern United States. Recent studies have demonstrated that vacuolar myelinopathy is induced by consumption of the epiphytic cyanobacterial species Aetokthonos hydrillicola growing on aquatic vegetation, primarily the invasive Hydrilla verticillata. Here, we describe the identification, biosynthetic gene cluster, and biological activity of aetokthonotoxin, a pentabrominated biindole alkaloid that is produced by the cyanobacterium A. hydrillicola. We identify this cyanobacterial neurotoxin as the causal agent of vacuolar myelinopathy and discuss environmental factors-especially bromide availability-that promote toxin production.

    Trvalý link: http://hdl.handle.net/11104/0319874

     
     
Počet záznamů: 1  

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