Gut Microbiota and Host Juvenile Growth

0488712 - MBÚ 2019 RIV US eng J - Článek v odborném periodiku
Schwarzer, Martin - Strigini, M. - Leulier, F.
Gut Microbiota and Host Juvenile Growth.
Calcified Tissue International and Calcified Tissue Research. Roč. 102, č. 4 (2018), s. 387-405. ISSN 0171-967X. E-ISSN 1432-0827
Grant ostatní: Nadační fond na podporu vědy(CZ) Neuron
Institucionální podpora: RVO:61388971
Klíčová slova: Germ free * Gnotobiology * Microbiota
Obor OECD: Microbiology
Impakt faktor: 3.265, rok: 2018

Good genes, good food, good friends. That is what parents hope will sustain and nurture the harmonious growth of their children. The impact of the genetic background and nutrition on postnatal growth has been in the spot light for long, but the good friends have come to the scene only recently. Among the good friends perhaps the most crucial ones are those that we are carrying within ourselves. They comprise the trillions of microbes that collectively constitute each individual's intestinal microbiota. Indeed, recent epidemiological and field studies in humans, supported by extensive experimental data on animal models, demonstrate a clear role of the intestinal microbiota on their host's juvenile growth, especially under suboptimal nutrient conditions. Genuinely integrative approaches applicable to invertebrate and vertebrate systems combine tools from genetics, developmental biology, microbiology, nutrition, and physiology to reveal how gut microbiota affects growth both positively and negatively, in healthy and pathological conditions. It appears that certain natural or engineered gut microbiota communities can positively impact insulin/IGF-1 and steroid hormone signaling, thus contributing to the host juvenile development and maturation.
Trvalý link: http://hdl.handle.net/11104/0283253