Počet záznamů: 1  

Post-transcriptional mending of gene sequences: looking under the hood of mitochondrial gene expression in diplonemids

  1. 1.
    0468794 - BC 2017 RIV US eng J - Článek v odborném periodiku
    Valach, M. - Moreira, S. - Faktorová, Drahomíra - Lukeš, Julius - Burger, G.
    Post-transcriptional mending of gene sequences: looking under the hood of mitochondrial gene expression in diplonemids.
    RNA biology. Roč. 13, č. 12 (2016), s. 1204-1211. ISSN 1547-6286. E-ISSN 1555-8584
    Grant CEP: GA ČR GA15-21974S
    Institucionální podpora: RVO:60077344
    Klíčová slova: Cryptic genes * gene fragmentation * trans-splicing * RNA editing * multipartite mtDNA * diplonemids
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.900, rok: 2016
    DOI: https://doi.org/10.1080/15476286.2016.1240143

    The instructions to make proteins and structural RNAs are laid down in gene sequences. Yet, in certain instances, these primary instructions need to be modified considerably during gene expression, most often at the transcript level. Here we review a case of massive post-transcriptional revisions via trans-splicing and RNA editing, a phenomenon occurring in mitochondria of a recently recognized protist group, the diplonemids. As of now, the various post-transcriptional steps have been cataloged in detail, but how these processes function is still unknown. Since genetic manipulation techniques such as gene replacement and RNA interference have not yet been established for these organisms, alternative strategies have to be deployed. Here, we discuss the experimental and bioinformatics approaches that promise to unravel the molecular machineries of trans-splicing and RNA editing in Diplonema mitochondria.

    Trvalý link: http://hdl.handle.net/11104/0266619

     
     
Počet záznamů: 1  

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