The role of the glucose-sensing transcription factor carbohydrate-responsive element-binding protein pathway in termite queen fertility

0461775 - ÚOCHB 2017 RIV GB eng J - Článek v odborném periodiku
Sillam-Dusses, D. - Hanus, Robert - Poulsen, M. - Roy, V. - Favier, M. - Vasseur-Cognet, M.
The role of the glucose-sensing transcription factor carbohydrate-responsive element-binding protein pathway in termite queen fertility.
Open Biology. Roč. 6, č. 5 (2016), č. článku 160080. E-ISSN 2046-2441
Grant CEP: GA ČR(CZ) GA14-12774S
Institucionální podpora: RVO:61388963
Klíčová slova: reproduction * phenotypic plasticity * carbohydrate-responsive element-binding protein * transcription factor * social insects * lipogenesis
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.481, rok: 2016
http://rsob.royalsocietypublishing.org/content/6/5/160080

Termites are among the few animals that themselves can digest the most abundant organic polymer, cellulose, into glucose. In mice and Drosophila, glucose can activate genes via the transcription factor carbohydrate-responsive element-binding protein (ChREBP) to induce glucose utilization and de novo lipogenesis. Here, we identify a termite orthologue of ChREBP and its downstream lipogenic targets, including acetyl-CoA carboxylase and fatty acid synthase. We show that all of these genes, including ChREBP, are upregulated in mature queens compared with kings, sterile workers and soldiers in eight different termite species. ChREBP is expressed in several tissues, including ovaries and fat bodies, and increases in expression in totipotent workers during their differentiation into neotenic mature queens. We further show that ChREBP is regulated by a carbohydrate diet in termite queens. Suppression of the lipogenic pathway by a pharmacological agent in queens elicits the same behavioural alterations in sterile workers as observed in queenless colonies, supporting that the ChREBP pathway partakes in the biosynthesis of semiochemicals that convey the signal of the presence of a fertile queen. Our results highlight ChREBP as a likely key factor for the regulation and signalling of queen fertility.
Trvalý link: http://hdl.handle.net/11104/0261359