Subdural infusion of dexamethasone inhibits leukomyelitis after acute spinal cord injury in a rat model

0450830 - ÚEM 2016 RIV PL eng J - Článek v odborném periodiku
Kwiecien, J. M. - Jarocz, B. - Machová-Urdzíková, Lucia - Rola, R. - Dabrowski, W.
Subdural infusion of dexamethasone inhibits leukomyelitis after acute spinal cord injury in a rat model.
Folia Neuropathologica. Roč. 53, č. 1 (2015), s. 41-51. ISSN 1641-4640. E-ISSN 1509-572X
Institucionální podpora: RVO:68378041
Klíčová slova: spinal cord injury * leukomyelitis * macrophages * subdural infusion * dexamethasone
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 1.233, rok: 2015

Trauma in spinal cord injury often results in massive damage to the white matter and in damage to myelin that results in a severe phagocyte-rich infiltration apparently directed at removing immunologically toxic myelin debris. In the epidural balloon crush injury to the rat cranial thoracic spinal cord, the dorsal column was crushed, which at one week post-op resulted in its obliteration by a severe infiltration by a virtually pure population of macrophages that internalized all damaged myelin. A week-long subdural infusion of dexamethasone, a stable synthetic corticosteroid, resulted in remarkable inhibition of the macrophage infiltration of the crush cavity and in the lack of removal of myelin debris by phagocytosis. In this study we demonstrated that spinal cord injury results in a severe inflammatory response directed at massively damaged myelin, and we inhibited this response with a subdural infusion of a powerful anti-inflammatory drug, dexamethasone.
Trvalý link: http://hdl.handle.net/11104/0253293