Binding abilities of copper to phospholipids and transport of oxalate

0444181 - ÚOCHB 2016 RIV AT eng J - Článek v odborném periodiku
Jaklová Dytrtová, Jana - Jakl, M. - Nováková, Kateřina - Navrátil, Tomáš - Šádek, Vojtěch
Binding abilities of copper to phospholipids and transport of oxalate.
Monatshefte fur Chemie. Roč. 146, č. 5 (2015), s. 831-837. ISSN 0026-9247. E-ISSN 1434-4475
Grant CEP: GA ČR GP13-21409P; GA ČR(CZ) GAP208/12/1645
Institucionální podpora: RVO:61388963 ; RVO:61388955
Klíčová slova: copper cations * dipalmitoylphosphatidylcholine (lecithin) * ESI-MS * impedance spectroscopy * oxalic acid * voltammetry * membrane
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 1.131, rok: 2015

Cu(II) creates complexes with dipalmitoylphosphatidylcholine (lecithin), which are detectable using electrospray ionization mass spectrometry. Lecithin (L) as a relatively big ligand prevents Cu(II) reduction to Cu(I) during the electrospray process. The detected complexes include (1) dications with a general formula: [Cu(L) (n) ](2+), where n prevails from 2 to 5 (in the m/z range from 50 to 2,000); and (2) monocations originated from the metal salt precursor [CuCl(L) (k) ](+) (k is 1 or 2). The Cu(II)/lecithin complexes are stable enough (appearance energy higher than 200 kJ mol(-1)) to utilize Cu(II) for stabilization of an artificial membrane. The impermeability of an artificial phospholipid membrane for oxalic acid and its complexes with copper ions in slightly acidic pH 5 was confirmed voltammetrically. However, adsorption of copper-oxalate complexes on the membrane surface was proved using electrochemical impedance spectroscopy.
Trvalý link: http://hdl.handle.net/11104/0246784