Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters

0435165 - BFÚ 2015 RIV NL eng J - Článek v odborném periodiku
Hofer, Michal - Pospíšil, Milan - Dušek, L. - Hoferová, Zuzana - Komůrková, Denisa
Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters.
Purinergic Signalling. Roč. 10, č. 3 (2014), s. 509-514. ISSN 1573-9538. E-ISSN 1573-9546
Grant CEP: GA ČR(CZ) GAP303/11/0128
Institucionální podpora: RVO:68081707
Klíčová slova: Adenosine A(3) receptor * Adenosine A(3) receptor knockout mice * Hematopoiesis
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 3.886, rok: 2014

The role of the adenosine A(3) receptor in hematopoiesis was studied using adenosine A(3) receptor knockout (A(3)AR KO) mice. Hematological parameters of peripheral blood and femoral bone marrow of irradiated and untreated A(3)AR KO mice and their wild-type (WT) counterparts were investigated. Irradiation of the mice served as a defined hematopoiesis-damaging means enabling us to evaluate contingent differences in the pattern of experimentally induced hematopoietic suppression between the A(3)AR KO mice and WT mice. Defects were observed in the counts and/or functional parameters of blood cells in the A(3)AR KO mice. These defects include statistically significantly lower values of blood neutrophil and monocyte counts, as well as those of mean erythrocyte volume, mean erythrocyte hemoglobin, blood platelet counts, mean platelet volume, and plateletcrit, and can be considered to bear evidence of the lack of a positive role played by the adenosine A(3) receptor in the hematopoietic system.
Trvalý link: http://hdl.handle.net/11104/0239092