Počet záznamů: 1
Cyclin D1 splice site variant triggers chromosomal aberrations in healthy humans
- 1.0432539 - ÚEM 2015 RIV GB eng J - Článek v odborném periodiku
Hemminki, K. - Mušák, L. - Vymetálková, Veronika - Šmerhovský, Z. - Halásová, E. - Osina, O. - Letková, L. - Försti, A. - Vodičková, Ludmila - Buchancová, J. - Vodička, Pavel
Cyclin D1 splice site variant triggers chromosomal aberrations in healthy humans.
Leukemia. Roč. 28, č. 3 (2014), s. 721-722. ISSN 0887-6924. E-ISSN 1476-5551
Institucionální podpora: RVO:68378041
Klíčová slova: chromosomal aberrations * DNA repair
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 10.431, rok: 2014
The present results on 730 healthy individuals show that the cyclin D1 splice site polymorphism is associated with an increased frequency of lymphocyte CAs. The known biology of the splice site variant is consistent in assigning allele A, encoding isoform 1b, with an increased CA frequency as this isoform lacks DNA damage response. The present findings suggest a biological basis for the link between CAs and cancer risk. Moreover, they provide the first evidence on a genetic control of the overall CA frequency.
Trvalý link: http://hdl.handle.net/11104/0236882
Počet záznamů: 1