Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice

0431306 - FGÚ 2015 RIV GB eng J - Článek v odborném periodiku
Teodoro, J.S. - Zouhar, Petr - Flachs, Pavel - Bardová, Kristina - Janovská, Petra - Gomes, A.P. - Duarte, F.V. - Varela, A.T. - Rolo, A.P. - Palmeira, C.M. - Kopecký, Jan
Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice.
International Journal of Obesity. Roč. 38, č. 8 (2014), s. 1027-1034. ISSN 0307-0565. E-ISSN 1476-5497
Grant CEP: GA MŠMT(CZ) 7E12073; GA ČR(CZ) GA13-00871S
Institucionální podpora: RVO:67985823
Klíčová slova: white adipose tissue * uncoupling protein 1 * energy expenditure * bile acids
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
Impakt faktor: 5.004, rok: 2014

In this study, the effects of natural bile acid, chenodeoxycholic acid (CDCA), on dietary obesity, UCP1 in both interscapular BAT and in white adipose tissue (brite cells in WAT), were characterized in dietary-obese mice. In the 8-week reversion, the CDCA intervention resulted in a dose-dependent reduction of obesity, dyslipidaemia and glucose intolerance, which could be largely explained by a transient decrease in food intake. The 3-week reversion revealed mild CDCA-dependent and food intake-independent induction of UCP1-mediated thermogenesis in interscapular BAT, negligible increase of UCP1 in subcutaneous WAT and a shift from carbohydrate to lipid oxidation
Trvalý link: http://hdl.handle.net/11104/0235883