Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats

0390670 - FGÚ 2013 RIV CH eng J - Článek v odborném periodiku
Vaněčková, Ivana - Kujal, P. - Husková, Z. - Vaňourková, Z. - Vernerová, Z. - Čertíková - Chábová, V. - Škaroupková, P. - Kramer, H. J. - Tesař, V. - Červenka, L.
Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats.
Kidney & Blood Pressure Research. Roč. 35, č. 5 (2012), s. 382-392. ISSN 1420-4096. E-ISSN 1423-0143
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: 5/6 nephrectomy * Endothelin receptor type A * AT1 receptor blocker * end-organ damage * hypertension
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 1.596, rok: 2012

The additive effect of endothelin-1 blockade to renin-angiotensin blockade was evaluated in rats with ablation nephrectomy. While RAS blockade normalized blood pressure (BP), improved survival, decreased cardiac hypertrophy and proteinuria as well as tissue angiotensin II and ET-1 levels, ETA receptor blockade only partially improved survival rate, reduced BP, attenuated the development of cardiac hypertrophy and transiently reduced proteinuria. No additive cardio- and renoprotective effects of ETA and RAS blockade were noted at the end of the study suggesting that the RAS system is the main target for antihypertensive treatment in models with inappropriately activated RAS
Trvalý link: http://hdl.handle.net/11104/0219579