Počet záznamů: 1
Isotope exchange reactions of the hydrogen H-5 of selected pyrimidine derivatives and the preparation of tritium-labeled pyrimidines
- 1.0388747 - ÚOCHB 2013 RIV CZ eng J - Článek v odborném periodiku
Dračínský, Martin - Jansa, Petr - Elbert, Tomáš
Isotope exchange reactions of the hydrogen H-5 of selected pyrimidine derivatives and the preparation of tritium-labeled pyrimidines.
Collection of Czechoslovak Chemical Communications. Roč. 76, č. 12 (2011), s. 1567-1577. ISSN 0010-0765
Grant CEP: GA AV ČR KJB400550903; GA MŠMT 1M0508
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: isotopic labeling * NMR spectroscopy * nucleobases * pyrimidines
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 1.283, rok: 2011
The hydrogen-to-deuterium isotope exchange reaction of hydrogen in position 5 of pyrimidine derivatives was studied using NMR techniques. The dependence of the reaction rate on the pH and on the solvent composition was explored. In tracer experiments using tritiated water, the application of this exchange reaction was tested for the preparation of pyrimidine derivatives labeled by tritium.
Trvalý link: http://hdl.handle.net/11104/0217699
Počet záznamů: 1