The coiled coil motif in polymer drug delivery systems

0388063 - ÚMCH 2013 RIV GB eng J - Článek v odborném periodiku
Pechar, Michal - Pola, Robert
The coiled coil motif in polymer drug delivery systems.
Biotechnology Advances. Roč. 31, č. 1 (2013), s. 90-96. ISSN 0734-9750. E-ISSN 1873-1899
Grant CEP: GA ČR GA203/08/0543; GA MŠMT 1M0505
Výzkumný záměr: CEZ:AV0Z40500505
Klíčová slova: coiled coil * hydrophilic polymer * recombinant protein
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 8.905, rok: 2013

The coiled coil is a superhelical structural protein motif that has been thoroughly investigated in recent years. Because of the relatively well-understood principles that determine the properties of coiled coil peptides and proteins, macromolecular systems containing the coiled coil motif have been suggested for various applications. This short review focuses on hybrid polymer coiled coil systems designed for drug delivery purposes. After a short introduction, the most important features of the coiled coils (stability, association number, oligomerization selectivity and orientation of helices) are described, and the factors influencing these characteristics are discussed. Several examples of the most interesting biomedical applications of the polymer-coiled coil systems (according to the authors' opinion) are presented.
Trvalý link: http://hdl.handle.net/11104/0217245