0383512 - ÚMCH 2013 RIV NL eng J - Článek v odborném periodiku
Urbanová, Martina - Brus, Jiří - Šeděnková, Ivana - Policianová, Olivia - Kobera, Libor
Characterization of solid polymer dispersions of active pharmaceutical ingredients by 19F MAS NMR and factor analysis.
Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy. Roč. 100, 1 January (2013), s. 59-66. ISSN 1386-1425. E-ISSN 1873-3557
Grant CEP: GA ČR GPP106/11/P426; GA MŠMT 2B08021
Výzkumný záměr: CEZ:AV0Z40500505
Institucionální podpora: RVO:61389013
Klíčová slova: solid-state NMR * factor analysis * 19F MAS NMR
Kód oboru RIV: FR - Farmakologie a lékárnická chemie
Impakt faktor: 2.129, rok: 2013 ; AIS: 0.35, rok: 2013
DOI: https://doi.org/10.1016/j.saa.2012.02.057

In this contribution the ability of 19F MAS NMR spectroscopy to probe structural variability of poorly water-soluble drugs formulated as solid dispersions in polymer matrices is discussed. The application potentiality of the proposed approach is demonstrated on a moderately sized active pharmaceutical ingredient (API, Atorvastatin) exhibiting extensive polymorphism. In this respect, a range of model systems with the API incorporated in the matrix of polvinylpyrrolidone (PVP) was prepared.
Trvalý link: http://hdl.handle.net/11104/0216060